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Research supports immune dysfunction in bipolar disorder

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oobydoobie
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Research supports immune dysfunction in bipolar disorder

Postby oobydoobie » Wed May 23, 2012 12:20 pm

Patients with bipolar disorder display altered plasma chemokine profiles compared with mentally healthy individuals, indicating that the mood disorder is associated with immune dysfunction.

Antônio Lúcio Teixeira (Universidade Federal de Minas Gerais, Belo Horizonte, Brazil) and colleagues explain that "recent evidence has suggested that inflammatory and immune mechanisms may play a role in the pathophysiology of bipolar disorder."

But they add that few studies have investigated levels of chemokines - small proteins defined by their ability to direct the movement of circulating leukocytes to sites of inflammation or injury - in patients with the mood disorder.

To investigate further, the team studied blood samples collected from 70 patients with bipolar I disorder, and 50 age-, gender-, and education level-matched mentally healthy individuals (controls).

Of the bipolar disorder patients, 35 were euthymic and 35 were experiencing an episode of mania at the time of the study. The mean length of illness was 23.4 years and 64.3% were women.

Enzyme-linked immunosorbent assays were used to measure and compare plasma levels of the chemokines CCL2, CCL3, CCL11, CCL24, CXCL8, and CXCL10 between the groups.

The team found that plasma levels of CCL11, CCL24, and CXCL10 were significantly higher in bipolar disorder patients compared with controls, at means of 980.63 versus 579.25 pg/mL, 1203.04 versus 856.63 pg/mL, and 197.85 versus 136.85 pg/mL, respectively.

Conversely, plasma levels of CXCL8 were significantly lower in bipolar disorder patients compared with controls, at 49.19 versus 425.92 pg/mL.

The findings remained largely unchanged after categorizing bipolar disorder patients according to mood state, except that CCL24 levels were found to be higher in euthymic patients compared with controls, but similar in manic patients and controls.

Chemokines levels were not associated with psychiatric comorbidities, substance dependence, or medication use in the bipolar disorder patients, the researchers note.

"Our data reinforce the view that there is an immunological imbalance associated with bipolar disorder trait," Teixeira et al conclude in the European Archives of Psychiatry and Clinical Neuroscience.


http://www.medwire-news.md/47/99579/Psy ... order.html
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umbrella4therain
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Re: Research supports immune dysfunction in bipolar disorder

Postby umbrella4therain » Wed May 23, 2012 12:26 pm

interesting. thanks for posting that ooby. xx

deadchick07
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Re: Research supports immune dysfunction in bipolar disorder

Postby deadchick07 » Wed May 23, 2012 10:49 pm

that's very interesting, there is a higher than average percentage number of bipolar people with M.E. and fibromyalgia compared to the general population, both illnesses thought to have roots in immunology problems. Very interesting indeed.
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oobydoobie
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Re: Research supports immune dysfunction in bipolar disorder

Postby oobydoobie » Thu May 24, 2012 12:30 am

They should take your physical problems seriously then regardless of your age.
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wishbone
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Re: Research supports immune dysfunction in bipolar disorder

Postby wishbone » Thu May 24, 2012 8:47 am

Thanks ooby,
I think this could be significant in many conditions.


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