It noted that some SGAs have a lower risk of weight-related side effects, and gave doctors information they need to pick low-risk drugs for patients with weight problems.
Clozaril and Zyprexa, the panel said, carry the highest risk of such side effects. Risperdal and Seroquel have an intermediate risk, while Geodon and Abilify cause little or none.
A likely mechanism by which antipsychotic medications trigger weight gain — with its attendant risks of heart disease, diabetes and treatment non-adherence — has been unraveled in mice by NIMH-funded scientists. They demonstrated that an antipsychotic boosted activity of an appetite-inducing enzyme four-fold in a brain region that regulates eating, by blocking a receptor
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